In Uruguay operate major car rental agencies worldwide. Major cities where you can make reservations are Montevideo, Punta del Este, Colonia, Paysandú, Fray Bentos, Mercedes and Tacuarembó. Agencies also are present in Carrasco airport (Montevideo), and Punta del Este.
However, there are agencies that extend Uruguayan cities offer rent or leave your car including Caramel, Peach, Melo and Swiss Colony in the center of the country. In all these destinations agencies do not charge fees for Drop Off, ie contract rent in one city and leave it in another city or at the airport.